Highly selective base-catalyzed ring closing Ugi-adducts from the reaction of 2-formylindole, 2-bromoacetic acid, amines and isocyanides
نویسندگان
چکیده
منابع مشابه
Copper-catalyzed synthesis of 2-aminobenzothiazoles from 2-iodophenyl isocyanides, potassium sulfide and amines.
A simple and practically useful synthetic method for the synthesis of a variety of 2-aminobenzothiazoles was developed. This methodology could construct one C-N bond and two C-S bonds in a step reaction and provide the desired products in good to perfect yields.
متن کاملSequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins
A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary functionalities for further transformations. The Ugi adducts were then subjected to a base-induced ring closing and an intramolecular azide-alky...
متن کاملSynthesis and Biological Evaluation of Novel Quinoline Derivatives as Antibacterial and Antifungal Agents
Vilsmeier Several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via Ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. The diversity of these quinolinyl Ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. Among them, compounds 2d, 2n, 2p, 4a, 4c and<strong...
متن کاملFormal [3+2] cycloaddition of Ugi adducts towards pyrrolines.
Ugi adducts derived from aromatic aldehydes may be converted to pyrrolines via addition of Michael acceptors under microwave irradiation. The reaction may proceed via unusual formation of azomethine ylides followed by a [3+2] cycloaddition using Michael acceptors.
متن کاملLewis Acid and/or Lewis Base catalyzed [3+2] cycloaddition reaction: Synthesis of pyrazoles and pyrazolines
Abstract: A facile, 1,3-dipolar cycloaddition of ethyl diazoacetate (EDA) with various activated olefins including Baylis-Hillman adducts, activated and simple alkynes to afford 3,5-disubstituted pyrazolines and pyrazoles respectively in moderate to good yields, in high regioselective manner in the presence of Indium chloride and/or DABCO is reported. All the reactions were carried out under no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Iranian Chemical Society
سال: 2014
ISSN: 1735-207X,1735-2428
DOI: 10.1007/s13738-014-0495-6